Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.47 |
| ▸ | DDX3X | O00571 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341663 | 0.89 | CXCR1 (0.59) | CXCR2KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL6567648 | 0.86 | CXCR2 (0.72) | CXCR2KMT2AMEN1RAB9AMAPT | |
| SCHEMBL5195764 | 0.82 | KMT2A (0.64) | CXCR2KMT2AMEN1RAB9AMAPT | |
| SCHEMBL5595504 | 0.80 | CXCR1 (0.66) | CXCR2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL5605320 | 0.79 | CXCR2 (1.00) | CXCR2KMT2AMEN1RAB9AMAPT | |
| SCHEMBL30051979 | 0.79 | MAPT (0.67) | KMT2AMEN1RAB9AMAPTGAA | |
| SCHEMBL11575411 | 0.78 | RAB9A (0.60) | CXCR2KMT2AMEN1RAB9AMAPT | |
| SCHEMBL6568502 | 0.78 | RAB9A (0.68) | CXCR2KMT2AMEN1RAB9AMAPT | |
| SCHEMBL5595289 | 0.77 | CXCR1 (0.73) | CXCR2KMT2AMEN1RAB9AMAPT | |
| SCHEMBL6436269 | 0.77 | MEN1 (0.72) | CXCR2KMT2AMEN1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |