Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | TACR1 | P25103 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HTR1E | P28566 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383257 | 0.80 | POLB (1.00) | POLBTACR1KMT2AMEN1MAPT | |
| SCHEMBL13949529 | 0.80 | MEN1 (0.66) | POLBTACR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4342381 | 0.77 | KMT2A (0.68) | POLBKMT2AMEN1MAPTLMNA | |
| SCHEMBL10954177 | 0.76 | POLB (0.76) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4341392 | 0.76 | NPC1 (0.70) | KMT2AMEN1MAPTLMNAHTT | |
| SCHEMBL6567231 | 0.75 | MEN1 (0.50) | TACR1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL13166707 | 0.74 | NPY2R (0.77) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1706750 | 0.74 | DHODH (0.54) | POLBKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL6568615 | 0.73 | ROCK2 (0.54) | LMNAL3MBTL1DHODHKDM4ESMN1; SMN2 | |
| SCHEMBL23715874 | 0.72 | POLB (0.76) | POLBTACR1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |