Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.51 |
| ▸ | GABRE | P78334 | 1/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031773 | 0.85 | TRPV1 (0.59) | TRPV1HPGDTP53GLAAPEX1 | |
| SCHEMBL14698338 | 0.82 | APEX1 (0.59) | TRPV1HPGDTP53GLAAPEX1 | |
| SCHEMBL30520585 | 0.81 | APEX1 (0.58) | TRPV1HPGDTP53GLAAPEX1 | |
| SCHEMBL21623922 | 0.81 | APEX1 (0.58) | TRPV1HPGDTP53GLAAPEX1 | |
| SCHEMBL5681720 | 0.79 | ERCC1 (0.69) | TRPV1PTPN7DUSP3SMN1; SMN2 | |
| SCHEMBL30386504 | 0.78 | APEX1 (0.56) | TRPV1HPGDTP53GLAAPEX1 | |
| SCHEMBL3455177 | 0.77 | LMNA (0.54) | HPGDAPEX1LMNAALDH1A1CYP1A2 | |
| SCHEMBL7715505 | 0.77 | DUSP3 (0.65) | PTPN7DUSP3SMN1; SMN2 | |
| SCHEMBL898313 | 0.77 | PTPN7 (0.54) | PTPN7DUSP3HPGDALDH1A1CYP1A2 | |
| SCHEMBL5065598 | 0.76 | NR1H4 (0.64) | PTPN7DUSP3HPGDLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |