Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12231039 | 0.86 | NPC1 (0.70) | HTTL3MBTL1MEN1KMT2ANAMPT | |
| SCHEMBL4341392 | 0.83 | NPC1 (0.70) | HTTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3050069 | 0.81 | MEN1 (0.67) | HTTL3MBTL1MEN1KMT2ANAMPT | |
| SCHEMBL7623733 | 0.79 | KMT2A (0.64) | HTTL3MBTL1MEN1KMT2ANAMPT | |
| SCHEMBL19337557 | 0.78 | KCNK3 (0.72) | HTTL3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL4347822 | 0.76 | KMT2A (0.68) | HTTL3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL4347446 | 0.74 | MAPT (0.66) | HTTNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL6566816 | 0.72 | POLB (0.69) | L3MBTL1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6567231 | 0.72 | MEN1 (0.50) | HTTMEN1KMT2ADHODHMAPT | |
| SCHEMBL1458502 | 0.72 | NPC1 (0.55) | L3MBTL1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |