Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.63 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30927212 | 1.00 | CYP19A1 (0.74) | CYP19A1LMNARAB9AKEAP1NAMPT | |
| SCHEMBL20946446 | 0.87 | CYP19A1 (0.72) | CYP19A1LMNARAB9ANAMPTTRPV1 | |
| SCHEMBL13888909 | 0.85 | KEAP1 (0.63) | CYP19A1LMNARAB9AKEAP1SMN1; SMN2 | |
| SCHEMBL21048461 | 0.84 | KEAP1 (0.81) | CYP19A1LMNAKEAP1SMN1; SMN2CA1 | |
| SCHEMBL14094673 | 0.84 | CYP19A1 (0.67) | CYP19A1LMNARAB9ANAMPTTRPV1 | |
| SCHEMBL14129032 | 0.84 | CYP19A1 (0.67) | CYP19A1LMNARAB9ANAMPTTRPV1 | |
| SCHEMBL22489364 | 0.83 | CYP19A1 (0.63) | CYP19A1LMNARAB9ANAMPTTRPV1 | |
| SCHEMBL1954496 | 0.83 | CYP19A1 (0.80) | CYP19A1LMNARAB9AKEAP1NAMPT | |
| SCHEMBL3853891 | 0.83 | CYP19A1 (0.70) | CYP19A1LMNARAB9AKEAP1NAMPT | |
| SCHEMBL13972872 | 0.83 | CYP19A1 (0.66) | CYP19A1LMNARAB9ANAMPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103588697-B | Disubstituted benzenes sulfamide compound of one class 2,5 and its production and use | 中国科学院上海药物研究所 | 2017-09-15 | — | — | CN | claimed |
| CN-103588697-B | Disubstituted benzenes sulfamide compound of one class 2,5 and its production and use | 中国科学院上海药物研究所 | 2017-09-15 | — | — | CN | disclosed |
| CN-102802731-A | Benzimidazole derivatives useful as TRPM8 channel modulators | JANSSEN PHARMACEUTICA NV | 2012-11-28 | — | — | CN | disclosed |
| EP-1443041-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-08-04 | — | — | EP | disclosed |