Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566909 | 0.86 | KMT2A (0.51) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6567640 | 0.85 | HTT (0.65) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4358325 | 0.83 | POLB (0.60) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4341979 | 0.78 | POLB (0.54) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11754054 | 0.78 | SMN1; SMN2 (0.63) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11685462 | 0.78 | SMN1; SMN2 (0.63) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2008813 | 0.76 | ALDH1A1 (0.70) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL31054226 | 0.75 | SMN1; SMN2 (0.71) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11676119 | 0.75 | HTT (0.63) | POLBHTTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1291893 | 0.74 | SMN1; SMN2 (0.70) | POLBHTTKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |