Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567544 | 0.86 | POLB (0.56) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL6649644 | 0.85 | EPHX2 (0.58) | MAPTALDH1A1HPGDNPSR1 | |
| SCHEMBL6568629 | 0.85 | IMPDH2 (0.58) | KMT2AMEN1MAPTSMN1; SMN2HTT | |
| SCHEMBL4344564 | 0.78 | HTT (0.53) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL4358325 | 0.78 | POLB (0.60) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL11676119 | 0.76 | HTT (0.63) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL4345612 | 0.75 | HTT (0.66) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL6565514 | 0.75 | POLB (0.66) | KMT2AMEN1MAPTSMN1; SMN2POLB | |
| SCHEMBL7284429 | 0.74 | TUBB4A (0.59) | KMT2AMEN1SMN1; SMN2POLBTRPV1 | |
| SCHEMBL4689726 | 0.74 | ALDH1A1 (0.58) | KMT2AMEN1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |