Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.57 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250817 | 0.87 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6567544 | 0.85 | POLB (0.56) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6568629 | 0.84 | IMPDH2 (0.58) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11754054 | 0.83 | SMN1; SMN2 (0.63) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11685462 | 0.83 | SMN1; SMN2 (0.63) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL31054226 | 0.81 | SMN1; SMN2 (0.71) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4342347 | 0.80 | HTT (0.70) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL10777166 | 0.80 | ALDH1A1 (0.68) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1291893 | 0.80 | SMN1; SMN2 (0.70) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11789681 | 0.78 | SMN1; SMN2 (0.67) | HTTSMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |