Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.72 |
| ▸ | MMP13 | P45452 | 17/20 | 0.72 |
| ▸ | MMP1 | P03956 | 16/20 | 0.72 |
| ▸ | ADAM17 | P78536 | 11/20 | 0.72 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566951 | 0.95 | MMP9 (0.72) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6568474 | 0.94 | MMP1 (0.73) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6568497 | 0.90 | MMP1 (0.71) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6567129 | 0.87 | MMP9 (0.73) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6567230 | 0.87 | MMP13 (0.73) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6568501 | 0.85 | MMP9 (0.71) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6567143 | 0.85 | MMP9 (0.71) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6568465 | 0.84 | MMP9 (0.69) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL6565380 | 0.84 | MMP9 (1.00) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL6565510 | 0.83 | MMP1 (0.73) | MMP9MMP13MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973512-B1 | N-HYDROXY-2-(ALKYL, ARYL OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH CORP (US) | 2004-04-07 | — | — | EP | claimed |