SCHEMBL6567678

SCHEMBL6567678

Cn1cc(N)c(-c2cccc(C(F)(F)F)c2)n1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.48
ADORA1 P30542 2/20 0.48
TLR8 Q9NR97 1/20 0.46
ALDH1A1 P00352 3/20 0.45
KDM4E B2RXH2 3/20 0.45
GABRA1 P14867 2/20 0.45
GABRG2 P18507 2/20 0.45
GABRB3 P28472 2/20 0.45
GABRA5 P31644 2/20 0.45
GABRA3 P34903 2/20 0.45
GABRA2 P47869 2/20 0.45
HSD17B10 Q99714 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
HPGD P15428 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
IKBKB O14920 1/20 0.45
BRD4 O60885 1/20 0.45
GABRP O00591 1/20 0.44
GABRD O14764 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15428594 0.80 ADCY10 (0.44) ADORA2AADORA1TLR8ALDH1A1KDM4E
SCHEMBL405378 0.78 ALDH1A1 (0.51) ADORA2AADORA1TLR8ALDH1A1KDM4E
SCHEMBL8842876 0.78 ADORA2A (0.47) ADORA2AADORA1ALDH1A1LMNANPSR1
SCHEMBL5457942 0.78 MAPK14 (0.57) MAPK1MAPK14KDR
SCHEMBL11717778 0.77 ALDH1A1 (0.50) ADORA2AADORA1ALDH1A1KDM4EGABRA1
SCHEMBL1799990 0.77 ADORA2A (0.48) ADORA2AADORA1TLR8ALDH1A1KDM4E
SCHEMBL544412 0.76 KDM4E (0.47) ADORA2AADORA1ALDH1A1KDM4EHSD17B10
SCHEMBL13854481 0.74 ALDH1A1 (0.44) ADORA2AADORA1TLR8ALDH1A1KDM4E
SCHEMBL11163991 0.74 ALDH1A1 (0.47) ADORA2AADORA1ALDH1A1KDM4ELMNA
SCHEMBL8035267 0.73 IKBKB (0.48) ADORA2AADORA1TLR8ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996034591-A1 DIAMINOPYRAZOLE-CONTAINING COMPOSITIONS FOR COLOURING KERATIN FIBRES, COLOURING PROCESS, NOVEL DIAMINOPYRAZOLES AND METHOD FOR THEIR PREPARATION L'OREAL (FR) 1996-11-07 WO claimed
EP-1404288-A2 COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A AMINO PYRAZOLE AND A CELLULOSE COMPOUND L'OREAL (FR) 2004-04-07 EP disclosed
EP-1345580-A1 COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A DIAMINO PYRAZOLE AND A CARBONYL COMPOUND L'OREAL (FR) 2003-09-24 EP disclosed
WO-2002051372-A2 COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A AMINO PYRAZOLE AND A CELLULOSE COMPOUND L'OREAL (FR) 2002-07-04 WO disclosed
WO-2002051373-A1 COMPOSITION FOR OXIDATION DYEING OF KERATINOUS FIBRES COMPRISING A DIAMINO PYRAZOLE AND A CARBONYL COMPOUND L'OREAL (FR) 2002-07-04 WO disclosed
EP-1011619-A1 DYEING COMPOSITION FOR KERATIN FIBRES L'OREAL (FR) 2000-06-28 EP disclosed
WO-1999011231-A1 DYEING COMPOSITION FOR KERATIN FIBRES L'OREAL (FR) 1999-03-11 WO disclosed