Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22092373 | 1.00 | KDM4E (0.42) | KDM4ECYP2C19RIPK1KMT2AL3MBTL1 | |
| SCHEMBL5649137 | 0.89 | RIPK1 (0.42) | KDM4ECYP2C19RIPK1HCRTR1HCRTR2 | |
| SCHEMBL5649142 | 0.89 | RIPK1 (0.42) | KDM4ECYP2C19RIPK1HCRTR1HCRTR2 | |
| SCHEMBL6646886 | 0.88 | CPT1A (0.42) | KDM4ECYP2C19RIPK1SCD5 | |
| SCHEMBL27860901 | 0.81 | RIPK1 (0.36) | RIPK1RAB9AHCRTR1HCRTR2 | |
| SCHEMBL17026995 | 0.73 | RIPK1 (0.67) | RIPK1SCD5 | |
| SCHEMBL1329027 | 0.70 | HSD11B1 (0.55) | RIPK1NPC1RAB9ASCD5 | |
| SCHEMBL3361751 | 0.69 | PRMT5 (0.56) | RIPK1NPC1RAB9ASCD5 | |
| SCHEMBL29785721 | 0.69 | PRMT5 (0.56) | RIPK1NPC1RAB9ASCD5 | |
| SCHEMBL20742564 | 0.69 | CPT1A (0.36) | RIPK1HCRTR1HCRTR2SCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440709-A2 | Combinations comprising cGMP PDE5 inhibitors. | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |
| EP-1285658-A2 | Treatments for female sexual dysfunction | Pfizer Productors Inc. (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1176147-A1 | Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof | Pfizer Limited (GB) | 2002-01-30 | — | — | EP | disclosed |
| EP-1176142-A1 | Process for the preparation of pyrazoles | PFIZER INC. (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-1149579-A2 | Use of an estrogen agonist/antagonist for treating female sexual dysfunction | Pfizer Products Inc. (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-1125582-A2 | Use of estrogen agonists / antagonists for the treatment of sexual dysfunction | Pfizer Products Inc. (US) | 2001-08-22 | — | — | EP | disclosed |