Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.46 |
| ▸ | CCR3 | P51677 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570421 | 0.82 | HRH1 (0.51) | HRH1CCR3KCNH2 | |
| SCHEMBL6569275 | 0.78 | HRH1 (0.46) | HRH1CCR3KCNH2ALDH1A1EGFR | |
| SCHEMBL6569255 | 0.74 | HRH1 (0.39) | HRH1CCR3KCNH2 | |
| SCHEMBL6569095 | 0.73 | HRH1 (0.42) | HRH1CCR3KCNH2UTS2R | |
| SCHEMBL6570601 | 0.73 | HRH1 (0.43) | HRH1CCR3KCNH2 | |
| SCHEMBL5412815 | 0.72 | HRH1 (0.84) | HRH1CCR3KCNH2 | |
| SCHEMBL5369367 | 0.70 | SLC6A2 (0.51) | HRH1UTS2R | |
| Hydrochloric Acid SCHEMBL4106087 | 0.69 | SLC6A2 (0.50) | HRH1UTS2R | |
| SCHEMBL6570411 | 0.68 | HRH1 (0.45) | HRH1CCR3KCNH2 | |
| SCHEMBL6569229 | 0.67 | HRH1 (0.47) | HRH1CCR3KCNH2UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404667-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004487-A1 | PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |