Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14815616 | 0.71 | GPR3 (0.43) | POLBACHEBCHEGPR3HTR2A | |
| SCHEMBL3922127 | 0.71 | GPR3 (0.46) | POLBACHEBCHEGPR3HTR2A | |
| SCHEMBL5837267 | 0.71 | GPR3 (0.46) | POLBACHEBCHEGPR3HTR2A | |
| SCHEMBL27563108 | 0.70 | CYP2C19 (0.44) | POLBALDH1A1CHRM1ADRA1ACYP1A2 | |
| SCHEMBL14825691 | 0.67 | POLB (0.40) | POLBALDH1A1PKMCYP1A2KMT2A | |
| SCHEMBL8971042 | 0.67 | GPR3 (0.43) | POLBACHEBCHEGPR3HTR2A | |
| SCHEMBL14825901 | 0.67 | POLB (0.39) | POLBALDH1A1PKMCYP1A2KMT2A | |
| SCHEMBL2547987 | 0.67 | ACHE (0.39) | POLBACHEBCHEGPR3HTR2A | |
| SCHEMBL21172113 | 0.66 | HDAC3 (0.46) | POLBALDH1A1PKMCYP1A2KMT2A | |
| SCHEMBL12205622 | 0.65 | POLB (0.44) | POLBGPR3ALDH1A1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404325-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002096420-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2002-12-05 | — | — | WO | disclosed |