Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.64 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | HTR2B | P41595 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.56 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | HTR2C | P28335 | 9/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14043228 | 0.86 | HTR7 (0.71) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL20186860 | 0.85 | HTR7 (0.59) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL31639048 | 0.85 | HTR7 (0.67) | HTR7CHRM4DRD2HTR2BMAPT | |
| Bromide SCHEMBL6569631 | 0.85 | HTR7 (0.70) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL20186853 | 0.83 | HTR2A (0.72) | HTR2BMAPKAPK2HTR2AHTR2C | |
| SCHEMBL5541281 | 0.82 | HTR7 (0.70) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL6240399 | 0.82 | HTR7 (0.70) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL6237647 | 0.82 | HTR7 (0.66) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL23116691 | 0.81 | HTR7 (0.67) | HTR7CHRM4DRD2HTR2BMAPT | |
| SCHEMBL18201330 | 0.80 | GRIN2B (0.62) | HTR7CHRM4DRD2MAPKAPK2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288921-B1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | UNIV COLORADO REGENTS (US) | 2022-06-15 | — | — | EP | disclosed |
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | IDO1, IDO2, INMT | HTR7 125/4885CHRM4 2641/4885DRD2 90/4885 |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | IDO1, IDO2, INMT | HTR7 125/4885CHRM4 2641/4885DRD2 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.