Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.74 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.74 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.74 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.74 |
| ▸ | PDK1 | Q15118 | 12/20 | 0.73 |
| ▸ | PDK2 | Q15119 | 12/20 | 0.73 |
| ▸ | PDK3 | Q15120 | 12/20 | 0.73 |
| ▸ | PDK4 | Q16654 | 12/20 | 0.73 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4607928 | 0.85 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6347722 | 0.84 | PDK1 (0.73) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6569428 | 0.84 | TSHR (0.71) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6351244 | 0.83 | PDK1 (0.71) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6569716 | 0.83 | PDK1 (0.67) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6569709 | 0.83 | PDK1 (0.67) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6567832 | 0.80 | PDK1 (0.66) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6567827 | 0.80 | PDK1 (0.66) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL6350417 | 0.79 | PDK1 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL15693330 | 0.77 | ALDH1A1 (0.62) | PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |