Sugi Predict

Sugi Predict / Compounds / SCHEMBL656983

SCHEMBL656983

SCHEMBL656983

NC(=O)c1ccc2cccccc1-2

nearest known ligand 0.88

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BCAT2 O15382 2/20 0.88
▸ IKBKB O14920 4/20 0.53
▸ NPC1 O15118 1/20 0.51
▸ RAB9A P51151 1/20 0.51
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ KDM4E B2RXH2 1/20 0.49
▸ CHRNB2 P17787 1/20 0.48
▸ CHRNB4 P30926 1/20 0.48
▸ CHRNA3 P32297 1/20 0.48
▸ CHRNA4 P43681 1/20 0.48
▸ CHEK1 O14757 1/20 0.47
▸ CASP1 P29466 1/20 0.47
▸ FGFR1 P11362 1/20 0.47
▸ SRC P12931 1/20 0.47
▸ FGFR2 P21802 1/20 0.47
▸ FGFR4 P22455 1/20 0.47
▸ FGFR3 P22607 1/20 0.47
▸ CRHBP P24387 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31140008 0.94 BCAT2 (0.92) BCAT2IKBKBNPC1RAB9AMEN1
SCHEMBL132986 0.93 BCAT2 (1.00) BCAT2IKBKBNPC1RAB9AMEN1
SCHEMBL29427545 0.93 BCAT2 (1.00) BCAT2IKBKBNPC1RAB9AMEN1
SCHEMBL28355265 0.91 BCAT2 (0.96) BCAT2IKBKBNPC1RAB9AMEN1
Ammonia Solution, Strong SCHEMBL28275782 0.91 BCAT2 (0.96) BCAT2IKBKBNPC1RAB9AMEN1
Hydrochloric Acid SCHEMBL1785690 0.91 BCAT2 (0.96) BCAT2IKBKBNPC1RAB9AMEN1
Hydrochloric Acid SCHEMBL27487444 0.91 BCAT2 (0.96) BCAT2IKBKBNPC1RAB9AMEN1
Hydrochloric Acid SCHEMBL5180095 0.91 BCAT2 (0.96) BCAT2IKBKBNPC1RAB9AMEN1
Urea SCHEMBL28572437 0.91 BCAT2 (0.96) BCAT2IKBKBNPC1RAB9AMEN1
Methane SCHEMBL27520060 0.91 BCAT2 (0.96) BCAT2IKBKBNPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108440528-A Fourth Ring Bu Luomo structural domain inhibitor 艾伯维公司 2018-08-24 — — CN claimed
CN-105026403-B Tetracyclic Bromodomain Inhibitors 艾伯维公司 2018-05-18 — — CN claimed
EP-2970330-A1 TETRACYCLIC BROMODOMAIN INHIBITORS AbbVie Inc. (US) 2016-01-20 — — EP claimed
CN-105026403-A Tetracyclic bromodomain inhibitors ABBVIE INC 2015-11-04 — — CN claimed
WO-2014139324-A1 TETRACYCLIC BROMODOMAIN INHIBITORS ABBVIE INC. (US) 2014-09-18 — — WO claimed
CN-116284382-B Procalcitonin-resistant antibodies and uses thereof 杭州华葵金配生物科技有限公司 2025-02-11 — — CN disclosed
US-20210188758-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS VTVX HOLDINGS II LLC 2021-06-24 — — US disclosed
US-10947180-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists VTV THERAPEUTICS LLC (US) 2021-03-16 — — US disclosed
US-20200215073-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS HIGH POINT PHARMACEUTICALS, LLC 2020-07-09 — — US disclosed
US-10471066-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists VTV THERAPEUTICS LLC (US) 2019-11-12 — — US disclosed
CN-108440528-A Fourth Ring Bu Luomo structural domain inhibitor 艾伯维公司 2018-08-24 — — CN disclosed
CN-105026403-B Tetracyclic Bromodomain Inhibitors 艾伯维公司 2018-05-18 — — CN disclosed
US-20050080115-A1 Novel compounds, their preparation and use NOVO NORDISK A/S (DK) 2005-04-14 — — US disclosed
US-20050070583-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2005-03-31 — — US disclosed
CN-1191255-C Benzodiazepine derivatives as GABA A receptor modulators HOFFMANN LA ROCHE (CH) 2005-03-02 — — CN disclosed
US-20040143006-A1 Novel compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC 2004-07-22 — — US disclosed
WO-2004037776-A2 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS NOVO NORDISK A/S (DK) 2004-05-06 — — WO disclosed
WO-2004037775-A1 NOVEL COMPOUNDS USEFUL IN TREATING PPAR MEDIATED DISEASES NOVO NORDISK A/S (DK) 2004-05-06 — — WO disclosed
WO-2004022533-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR THERAPEUTICAL USE NOVO NORDISK A/S (DK) 2004-03-18 — — WO disclosed
CN-1474820-A Benzodiazepine derivatives as GABA A receptor modulators - 2004-02-11 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10471066-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists PPARG, PPARA, PPARD BCAT2 971/4885IKBKB 1239/4885NPC1 3042/4885
US-20050070583-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA BCAT2 1753/4885IKBKB 1287/4885NPC1 500/4885
US-20050080115-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA BCAT2 1753/4885IKBKB 1287/4885NPC1 500/4885
US-20040143006-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA BCAT2 1729/4885IKBKB 1784/4885NPC1 546/4885
US-10947180-B2 Phenoxy acetic acids and phenyl propionic acids as PPAR delta agonists PPARG, PPARA, PPARD BCAT2 971/4885IKBKB 1239/4885NPC1 3042/4885
US-20200215073-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS PPARG, PPARA, PPARD BCAT2 971/4885IKBKB 1239/4885NPC1 3042/4885
US-20210188758-A1 PHENOXY ACETIC ACIDS AND PHENYL PROPIONIC ACIDS AS PPAR DELTA AGONISTS PPARG, PPARA, PPARD BCAT2 971/4885IKBKB 1239/4885NPC1 3042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.