Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 11/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568415 | 0.86 | TSHR (0.44) | S1PR1S1PR3S1PR4S1PR5NPC1 | |
| SCHEMBL6569232 | 0.85 | CA12 (0.43) | S1PR1S1PR3S1PR4S1PR5TSHR | |
| SCHEMBL6569146 | 0.84 | CETP (0.45) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL6570112 | 0.83 | TSHR (0.41) | S1PR1S1PR3S1PR4S1PR5NPC1 | |
| SCHEMBL6568406 | 0.83 | NPC1 (0.50) | POLBNPC1RAB9AALDH1A1ALOX12 | |
| SCHEMBL6571631 | 0.81 | GAA (0.43) | CYP3A4CYP2C19TSHR | |
| SCHEMBL6568562 | 0.81 | HDAC3 (0.44) | NPC1RAB9ATSHR | |
| SCHEMBL6570330 | 0.79 | TDP1 (0.46) | POLBNPC1RAB9A | |
| SCHEMBL6570338 | 0.78 | ALDH1A1 (0.41) | POLBNPC1RAB9AALDH1A1ALOX12 | |
| SCHEMBL6569921 | 0.78 | HDAC1 (0.51) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156054-B1 | DRUGS CONTAINING PHOSPHORIC ACID DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-04-14 | — | — | EP | claimed |
| US-6495533-B1 | TUMOR NECROSIS FACTOR INHIBITORS; RHEUMATOID ARTHRITIS, ULCERATIVE COLITIS, CROHN'S DISEASE, HEPATITIS, SEPSIS, HEMORRHAGIC SHOCK, MULTIPLE SCLEROSIS, CEREBRAL INFARCTION, DIABETES, INTERSTITIAL PNEUMONIA, PAIN, HIV | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | claimed |
| EP-1156054-A1 | DRUGS CONTAINING PHOSPHORIC ACID DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-11-21 | — | — | EP | claimed |