SCHEMBL6570756

SCHEMBL6570756

Cc1ccc(N)c(C)c1-c1cc(N)ccc1NCCO

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 2/20 0.37
TSHR P16473 1/20 0.35
PDE10A Q9Y233 1/20 0.35
ALDH1A1 P00352 4/20 0.34
BRD4 O60885 1/20 0.34
CYP2C19 P33261 2/20 0.33
KMT2A Q03164 3/20 0.33
GAA P10253 2/20 0.33
MEN1 O00255 2/20 0.33
MAPT P10636 2/20 0.33
NQO2 P16083 4/20 0.33
PLA2G7 Q13093 1/20 0.33
KDM4E B2RXH2 1/20 0.32
GLA P06280 1/20 0.32
HPGD P15428 1/20 0.32
TOP2B Q02880 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
SIGMAR1 Q99720 1/20 0.32
PRSS1 P07477 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574192 0.83 POLB (0.49) CASP1TSHRPDE10AALDH1A1BRD4
SCHEMBL6573315 0.82 KMT2A (0.37) TSHRALDH1A1CYP2C19KMT2ATOP2B
SCHEMBL6570871 0.81 AR (0.36) CASP1TSHRPDE10AKMT2AGAA
SCHEMBL6571976 0.81 TOP2B (0.37) BRD4CYP2C19KMT2AMEN1MAPT
SCHEMBL6572615 0.79 NSD2 (0.42) TSHRALDH1A1BRD4CYP2C19KMT2A
SCHEMBL6572081 0.79 HDAC6 (0.35) PDE10AALDH1A1BRD4CYP2C19KMT2A
SCHEMBL6572757 0.78 PLA2G7 (0.43) TSHRPDE10AALDH1A1BRD4CYP2C19
SCHEMBL9464298 0.78 TSHR (0.44) CASP1TSHRPDE10AALDH1A1BRD4
SCHEMBL29392615 0.78 CYP2C19 (0.45) CASP1TSHRPDE10AALDH1A1BRD4
SCHEMBL33660 0.78 CYP2C19 (0.45) CASP1TSHRPDE10AALDH1A1BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed