Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573690 | 0.81 | CYP3A4 (0.50) | MAPTCYP3A4NPC1ALDH1A1POLB | |
| SCHEMBL6569993 | 0.77 | LMNA (0.68) | MAPTCYP3A4BLMPMP22DRD2 | |
| SCHEMBL6572262 | 0.76 | SMN1; SMN2 (0.69) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL366651 | 0.75 | MAPT (0.55) | MAPTCYP3A4BLMPMP22NPC1 | |
| SCHEMBL6573702 | 0.75 | MAPT (0.59) | MAPTCYP3A4BLMPMP22NPC1 | |
| SCHEMBL6573527 | 0.75 | SMN1; SMN2 (0.65) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL8761909 | 0.74 | NPC1 (0.44) | MAPTCYP3A4NPC1ALDH1A1POLB | |
| SCHEMBL11120951 | 0.72 | MAPT (0.74) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL2977898 | 0.71 | MEN1 (0.44) | MAPTCYP3A4NPC1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9251441 | 0.71 | LMNA (0.43) | MAPTCYP3A4NPC1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | claimed |
| EP-1109550-B1 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2004-11-24 | — | — | EP | disclosed |
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | disclosed |