Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLR1A | O95602 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573507 | 0.84 | CYP19A1 (0.53) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL6569993 | 0.78 | LMNA (0.68) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL6570808 | 0.75 | MAPT (0.54) | MAPTALDH1A1L3MBTL1KMT2ACYP3A4 | |
| SCHEMBL6572262 | 0.74 | SMN1; SMN2 (0.69) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL6573527 | 0.73 | SMN1; SMN2 (0.65) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL366651 | 0.71 | MAPT (0.55) | MAPTALDH1A1SMN1; SMN2HTTMAPK1 | |
| SCHEMBL14552409 | 0.71 | CYP19A1 (0.60) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL7038359 | 0.71 | MAPT (0.64) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL11120951 | 0.69 | MAPT (0.74) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL10657230 | 0.68 | ALDH1A1 (0.69) | MAPTALDH1A1L3MBTL1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | claimed |
| EP-1109550-B1 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2004-11-24 | — | — | EP | disclosed |
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | disclosed |
| EP-1109550-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013683-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-16 | — | — | WO | disclosed |