Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | SHBG | P04278 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928978 | 0.99 | HSP90AB1 (0.50) | HSP90AB1HTTESR1SHBGESR2 | |
| Hydrochloric Acid SCHEMBL10528498 | 0.78 | POLB (0.45) | HTTPOLBALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6571040 | 0.78 | POLB (0.39) | HTTPOLBALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3847701 | 0.77 | ALDH1A1 (0.48) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| Bromide SCHEMBL10529434 | 0.77 | POLB (0.52) | POLBALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL10526750 | 0.77 | POLB (0.46) | HTTPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL2932487 | 0.76 | POLB (0.38) | POLBALDH1A1NPC1RAB9AKMT2A | |
| Bromide SCHEMBL10526865 | 0.76 | POLB (0.48) | HTTPOLBALDH1A1NPC1RAB9A | |
| Bromide SCHEMBL10528516 | 0.75 | POLB (0.47) | POLBRAB9AMEN1KMT2AGAA | |
| SCHEMBL10531099 | 0.73 | ERCC5 (0.43) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064267-B1 | NOVEL CATIONIC COUPLING AGENTS, THEIR USE FOR OXIDATION DYEING OF KERATINOUS FIBRES, DYEING COMPOSITIONS AND DYEING METHODS | OREAL (FR) | 2004-09-29 | — | — | EP | claimed |
| US-6461389-B1 | HAIR DYE | L'OREAL S.A. (FR) | 2002-10-08 | — | — | US | claimed |
| US-6451067-B1 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-09-17 | — | — | US | claimed |
| US-6461389-B1 | HAIR DYE | L'OREAL S.A. (FR) | 2002-10-08 | — | — | US | disclosed |
| US-6451067-B1 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-09-17 | — | — | US | disclosed |