Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932487 | 0.99 | POLB (0.38) | POLBCXCR1ALDH1A1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6570098 | 0.79 | LMNA (0.37) | POLBALDH1A1KMT2AL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL6571086 | 0.78 | HSP90AB1 (0.49) | POLBALDH1A1KMT2ALMNAHTT | |
| SCHEMBL2928925 | 0.78 | LMNA (0.35) | POLBALDH1A1KMT2AL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL5472880 | 0.77 | ALDH1A1 (0.51) | POLBALDH1A1KMT2ALMNACYP2C9 | |
| SCHEMBL2928978 | 0.76 | HSP90AB1 (0.50) | POLBALDH1A1KMT2ALMNAHTT | |
| Hydrochloric Acid SCHEMBL6569970 | 0.76 | MEN1 (0.46) | POLBALDH1A1KMT2AL3MBTL1MAPK1 | |
| SCHEMBL2922194 | 0.75 | ALDH1A1 (0.52) | POLBALDH1A1KMT2AL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL5526645 | 0.75 | HPGD (0.49) | KMT2ACYP1A2CYP2C19HTTRAB9A | |
| SCHEMBL2928995 | 0.74 | MEN1 (0.44) | POLBALDH1A1KMT2AL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064267-B1 | NOVEL CATIONIC COUPLING AGENTS, THEIR USE FOR OXIDATION DYEING OF KERATINOUS FIBRES, DYEING COMPOSITIONS AND DYEING METHODS | OREAL (FR) | 2004-09-29 | — | — | EP | claimed |
| US-6461389-B1 | HAIR DYE | L'OREAL S.A. (FR) | 2002-10-08 | — | — | US | claimed |
| US-6451067-B1 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-09-17 | — | — | US | claimed |
| US-6461389-B1 | HAIR DYE | L'OREAL S.A. (FR) | 2002-10-08 | — | — | US | disclosed |
| US-6451067-B1 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-09-17 | — | — | US | disclosed |