SCHEMBL6571982

SCHEMBL6571982

CC(F)(Cl)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
TSHR P16473 2/20 0.52
MAPK1 P28482 1/20 0.46
CYP1A2 P05177 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
ALOX15 P16050 1/20 0.42
ESR1 P03372 2/20 0.41
ESR2 Q92731 2/20 0.41
PTPN1 P18031 1/20 0.41
CYP3A4 P08684 1/20 0.41
KCNN4 O15554 3/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA5A P35218 1/20 0.39
CA9 Q16790 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
KIF11 P52732 1/20 0.39
CYP2C19 P33261 1/20 0.38
HIF1A Q16665 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13518151 0.79 ALDH1A1 (0.48) ALDH1A1TSHRMAPK1CYP1A2TAAR1
SCHEMBL11691261 0.78 TSHR (0.60) ALDH1A1TSHRMAPK1CYP1A2TAAR1
SCHEMBL4219815 0.77 TSHR (0.58) ALDH1A1TSHRMAPK1CYP1A2TAAR1
SCHEMBL6342232 0.77 ALDH1A1 (0.58) ALDH1A1TSHRMAPK1TAAR1ALOX15
SCHEMBL3621303 0.77 ALDH1A1 (0.58) ALDH1A1TSHRMAPK1TAAR1ALOX15
SCHEMBL686644 0.77 TSHR (0.58) ALDH1A1TSHRMAPK1CYP1A2TAAR1
SCHEMBL5720508 0.77 TSHR (0.58) ALDH1A1TSHRMAPK1CYP1A2TAAR1
SCHEMBL17885872 0.77 ALDH1A1 (0.58) ALDH1A1TSHRMAPK1TAAR1ALOX15
SCHEMBL13554 0.77 ALDH1A1 (0.58) ALDH1A1TSHRMAPK1TAAR1ALOX15
SCHEMBL2743453 0.77 TSHR (0.58) ALDH1A1TSHRMAPK1CYP1A2TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2864289-A1 CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS Crown Bioscience Inc. (Taiwan) (CN) 2015-04-29 EP disclosed
WO-2014000418-A1 CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS CROWN BIOSCIENCE INC. (TAICANG) (CN) 2014-01-03 WO disclosed
CN-1537091-A Method for producing 2-phenylacetophenone derivative, and precursor for producng the same 石原产业株式会社 2004-10-13 CN disclosed
EP-1463697-A2 SYNTHESIS OF ALFA,BETA,BETA-TRIFLUOROSTYRENE VIA IN-SITU FORMATION OF TRIFLUOROVINYL METAL HALIDE BALLARD POWER SYSTEMS INC. (CA) 2004-10-06 EP disclosed
WO-2003051801-A2 SYNTHESIS OF ALPHA, BETA, BETA-TRIFLUOROSTYRENE VIA IN-SITU FORMATION OF TRIFLUOROVINYL METAL HALIDE BALLARD POWER SYSTEMS INC. (CA) 2003-06-26 WO disclosed
US-4331821-A ULTRAVIOLET RADIATION OF A VAPORIZED ALKYLBENZEN AND HALOGEN GAS MIXTURE BAYER AKTIENGESELLSCHAFT (DE) 1982-05-25 US disclosed