SCHEMBL6572068

SCHEMBL6572068

Cc1ccc(-c2cc(N)ccc2N(CCO)CCO)cc1[N+](=O)[O-]

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.52
TSHR P16473 4/20 0.52
CYP3A4 P08684 2/20 0.52
RECQL P46063 1/20 0.52
KDM4E B2RXH2 1/20 0.39
NSD2 O96028 1/20 0.39
NCOA1 Q15788 1/20 0.39
NCOA3 Q9Y6Q9 1/20 0.39
PGR P06401 1/20 0.38
MAPT P10636 3/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HCAR3 P49019 1/20 0.37
ALOX15 P16050 2/20 0.37
MAPK1 P28482 1/20 0.37
HSD17B10 Q99714 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
TDP1 Q9NUW8 4/20 0.36
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574551 0.86 ALDH1A1 (0.50) ALDH1A1TSHRCYP3A4RECQLPGR
SCHEMBL6574162 0.79 ALDH1A1 (0.46) ALDH1A1TSHRCYP3A4RECQLKDM4E
SCHEMBL6572674 0.79 ALDH1A1 (0.47) ALDH1A1TSHRCYP3A4KDM4EMAPT
SCHEMBL6570740 0.78 ALDH1A1 (0.38) ALDH1A1TSHRKDM4EMAPTMEN1
SCHEMBL29410423 0.78 ALOX15 (0.51) ALDH1A1TSHRCYP3A4RECQLKDM4E
SCHEMBL871404 0.78 ALOX15 (0.51) ALDH1A1TSHRCYP3A4RECQLKDM4E
SCHEMBL6574654 0.78 ALDH1A1 (0.42) ALDH1A1TSHRCYP3A4RECQLKDM4E
SCHEMBL6570840 0.78 ALDH1A1 (0.36) ALDH1A1TSHRCYP3A4RECQLKDM4E
SCHEMBL5685395 0.77 TSHR (0.68) ALDH1A1TSHRCYP3A4RECQLMAPT
Hydrochloric Acid SCHEMBL6573276 0.76 TSHR (0.66) ALDH1A1TSHRCYP3A4RECQLMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed