SCHEMBL6574654

SCHEMBL6574654

Nc1ccc(N(CCO)CCO)c(-c2ccccc2[N+](=O)[O-])c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
TDP1 Q9NUW8 4/20 0.42
NSD2 O96028 1/20 0.42
NCOA1 Q15788 1/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
ALOX15 P16050 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40
KDM4E B2RXH2 1/20 0.40
TSHR P16473 3/20 0.39
CYP3A4 P08684 2/20 0.39
MEN1 O00255 1/20 0.38
PABPC1 P11940 1/20 0.38
KMT2A Q03164 1/20 0.38
MGAM O43451 1/20 0.37
GAA P10253 1/20 0.37
SI P14410 1/20 0.37
MGAM2 Q2M2H8 1/20 0.37
HCAR3 P49019 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6570712 0.84 TUBB4A (0.38) ALDH1A1TDP1ALOX15L3MBTL1MAPK1
SCHEMBL29410423 0.82 ALOX15 (0.51) ALDH1A1TDP1NSD2NCOA1NCOA3
SCHEMBL871404 0.82 ALOX15 (0.51) ALDH1A1TDP1NSD2NCOA1NCOA3
SCHEMBL6572068 0.78 ALDH1A1 (0.52) ALDH1A1TDP1NSD2NCOA1NCOA3
SCHEMBL6572419 0.78 MEN1 (0.40) ALDH1A1TDP1NSD2NCOA1ALOX15
SCHEMBL6572674 0.78 ALDH1A1 (0.47) ALDH1A1L3MBTL1MAPK1KDM4ETSHR
SCHEMBL6572969 0.77 ALDH1A1 (0.50) ALDH1A1TDP1ALOX15L3MBTL1KDM4E
SCHEMBL6573270 0.77 MEN1 (0.39) ALDH1A1TDP1NSD2NCOA1L3MBTL1
SCHEMBL6570701 0.77 PLA2G7 (0.43) ALDH1A1TDP1NSD2NCOA1MAPK1
SCHEMBL6574139 0.77 PLA2G7 (0.50) ALDH1A1TDP1MAPK1TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed