SCHEMBL6572289

SCHEMBL6572289

Nc1ccc(N)c(-c2cccc(Cl)c2Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 1/20 0.49
NUDT1 P36639 7/20 0.42
MAPK1 P28482 2/20 0.41
PMP22 Q01453 2/20 0.41
BLM P54132 2/20 0.41
CYP2D6 P10635 1/20 0.41
MAOA P21397 1/20 0.41
ADRA1A P35348 1/20 0.41
SCN4A P35499 1/20 0.41
PDE3A Q14432 1/20 0.41
SCN5A Q14524 1/20 0.41
SCN9A Q15858 1/20 0.41
SCN2A Q99250 1/20 0.41
SCN3A Q9NY46 1/20 0.41
SCN10A Q9Y5Y9 1/20 0.41
CYP3A4 P08684 4/20 0.40
TSHR P16473 4/20 0.40
ALDH1A1 P00352 4/20 0.40
HPGD P15428 2/20 0.40
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6574828 0.98 PLA2G7 (0.47) PLA2G7NUDT1MAPK1PMP22BLM
SCHEMBL2502453 0.85 TSHR (0.48) NUDT1MAPK1PMP22BLMCYP2D6
SCHEMBL452550 0.84 PLA2G7 (0.67) PLA2G7MAPK1PMP22BLMCYP3A4
Hydrochloric Acid SCHEMBL6570944 0.82 PLA2G7 (0.65) PLA2G7MAPK1PMP22BLMCYP3A4
SCHEMBL2498706 0.81 ALDH1A1 (0.41) NUDT1MAPK1PMP22BLMCYP2D6
SCHEMBL397466 0.79 ALDH1A1 (0.59) NUDT1MAPK1PMP22BLMCYP2D6
Hydrochloric Acid SCHEMBL28115566 0.78 ALDH1A1 (0.56) NUDT1MAPK1PMP22BLMCYP2D6
SCHEMBL27185966 0.77 PLA2G7 (0.49) PLA2G7MAPK1PMP22BLMCYP3A4
SCHEMBL31607633 0.77 PLA2G7 (0.49) PLA2G7MAPK1PMP22BLMCYP3A4
SCHEMBL15330139 0.76 NUDT1 (0.45) NUDT1MAPK1PMP22BLMCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed