Chloroform

Chloroform

SCHEMBL6572404

CC(=O)CC(Cl)(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl.ClC(Cl)Cl

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
TDP1 Q9NUW8 2/20 0.33
TRPA1 O75762 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloroform SCHEMBL7588983 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL537674 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL5242240 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL1070309 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL1947696 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL1948761 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL2459693 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL1949022 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL2754253 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1
Chloroform SCHEMBL9288979 1.00 ALDH1A1 (0.33) ALDH1A1TDP1TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1152037-B1 SQUARYLIUM COMPOUNDS AND OPTICAL RECORDING MEDIA MADE BY USING THE SAME KYOWA HAKKO KOGYO KK (JP) 2004-05-19 EP disclosed
US-6599605-B2 Digital versatile disc high density recording layer KYOWA HAKKO KOGYO CO., LTD. (JP) 2003-07-29 US disclosed
US-20030082329-A1 Squarylium compounds and optical recording media using the same KYOWA HAKKO CHEMICAL CO., LTD. (FORMERLY KYOWA YUKA CO., LTD.) (JP) 2003-05-01 US disclosed
EP-0685470-B1 Benzene derivatives and pharmaceutical composition KUREHA CHEMICAL IND CO LTD (JP) 2002-09-11 EP disclosed
EP-1152037-A9 SQUARYLIUM COMPOUNDS AND OPTICAL RECORDING MEDIA MADE BY USING THE SAME KYOWA HAKKO KOGYO CO., LTD. (JP) 2002-02-27 EP disclosed
EP-1152037-A1 SQUARYLIUM COMPOUNDS AND OPTICAL RECORDING MEDIA MADE BY USING THE SAME KYOWA HAKKO KOGYO CO., LTD. (JP) 2001-11-07 EP disclosed
US-5739131-A TREATMENT OF KIDNEY DISORDERS; COMPOUNDS DO NOT AFFECT BLOOD PRESSURE KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1998-04-14 US disclosed
US-5731310-A KIDNEY DISEASE KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1998-03-24 US disclosed
US-5696118-A ADMINISTERING FOR TREATING KIDNEY DISEASE KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1997-12-09 US disclosed
EP-0685470-A2 Benzene derivatives and pharmaceutical composition Kureha Chemical Industry Co., Ltd. (JP) 1995-12-06 EP disclosed
EP-0185814-B1 PHENYLSERINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1990-08-29 EP disclosed
US-4695580-A Phenylserine derivatives and processes for preparing the same SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) 1987-09-22 US disclosed