Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.53 |
| ▸ | MMP13 | P45452 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5898944 | 0.94 | MMP2 (0.54) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8361646 | 0.93 | MMP2 (0.51) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5898961 | 0.89 | MMP2 (0.52) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5898978 | 0.89 | MMP13 (0.60) | MMP2MMP13KMT2ASMN1; SMN2GAA | |
| SCHEMBL5898993 | 0.89 | MMP2 (0.49) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8361686 | 0.88 | MMP2 (0.47) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5898959 | 0.88 | MMP2 (0.48) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5899028 | 0.88 | MMP2 (0.55) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8361708 | 0.87 | MMP2 (0.52) | MMP2MMP13KMT2ASMN1; SMN2MAPT | |
| SCHEMBL5898986 | 0.86 | MMP13 (0.69) | MMP2MMP13KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406602-A2 | USE OF SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACIDS AND DERIVATIVES THEREOF AS AGGRECANASE INHIBITORS | Pharmacia Corporation (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003007954-A2 | SULFONYL ARYL HYDROXAMATES AND THEIR USE AS MATRIX METALLOPROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-01-30 | — | — | WO | disclosed |
| WO-2003007930-A2 | USE OF SULFONYL ARYL OR HETEROARYL HYDROXAMIC ACIDS AND DERIVATIVES THEREOF AS AGGRECANASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-01-30 | — | — | WO | disclosed |