Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 10/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 10/20 | 0.57 |
| ▸ | PDK3 | Q15120 | 10/20 | 0.57 |
| ▸ | PDK4 | Q16654 | 10/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.51 |
| ▸ | ABCC8 | Q09428 | 5/20 | 0.51 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.51 |
| ▸ | KCNJ8 | Q15842 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6449596 | 0.90 | ABCB11 (0.59) | MAPTALDH1A1ABCB11PDK1PDK2 | |
| SCHEMBL6571168 | 0.89 | ABCB11 (0.76) | ABCB11PDK1PDK2PDK3PDK4 | |
| SCHEMBL6571176 | 0.89 | ABCB11 (0.76) | ABCB11PDK1PDK2PDK3PDK4 | |
| SCHEMBL6350182 | 0.87 | ABCB11 (0.58) | MAPTALDH1A1ABCB11PDK1PDK2 | |
| SCHEMBL6570069 | 0.86 | PDK1 (0.60) | ABCB11PDK1PDK2PDK3PDK4 | |
| SCHEMBL6473333 | 0.85 | MAPT (0.56) | MAPTALDH1A1ABCB11PDK1PDK2 | |
| SCHEMBL6571101 | 0.85 | PDK1 (0.56) | MAPTALDH1A1ABCB11PDK1PDK2 | |
| SCHEMBL6350096 | 0.79 | ABCB11 (0.76) | ABCB11PDK1PDK2PDK3PDK4 | |
| SCHEMBL6350091 | 0.79 | ABCB11 (0.76) | ABCB11PDK1PDK2PDK3PDK4 | |
| SCHEMBL27760546 | 0.79 | ABCC9 (0.78) | MAPTALDH1A1ABCC9ABCC8KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-B1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 2004-03-24 | — | — | EP | disclosed |