Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PRKCG | P05129 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659439 | 0.84 | KDM4E (0.67) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| SCHEMBL4660820 | 0.84 | KDM4E (0.67) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| SCHEMBL5642916 | 0.84 | KDM4E (0.67) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| SCHEMBL6607705 | 0.78 | UTS2R (0.58) | ALDH1A1KDM4ELMNAHPGDMEN1 | |
| SCHEMBL29142735 | 0.77 | KDM4E (0.54) | KDM4ELMNAHPGDMEN1KMT2A | |
| SCHEMBL9848822 | 0.76 | ROCK2 (0.70) | KDM4ELMNAHPGDMEN1KMT2A | |
| SCHEMBL2777735 | 0.76 | ROCK2 (0.70) | KDM4ELMNAHPGDMEN1KMT2A | |
| SCHEMBL9293287 | 0.76 | ROCK2 (0.70) | KDM4ELMNAHPGDMEN1KMT2A | |
| SCHEMBL13947402 | 0.76 | LMNA (0.60) | ALDH1A1KDM4ELMNAHPGDTSHR | |
| SCHEMBL6602494 | 0.76 | UTS2R (0.60) | ALDH1A1KDM4EMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406617-A1 | DIAMINEDIOLS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-04-14 | — | — | EP | claimed |
| WO-2003006013-A1 | DIAMINEDIOLS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-01-23 | — | — | WO | claimed |