Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.62 |
| ▸ | PPARG | P37231 | 7/20 | 0.62 |
| ▸ | PPARD | Q03181 | 7/20 | 0.62 |
| ▸ | PPARA | Q07869 | 7/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.62 |
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TLR2 | O60603 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | FABP4 | P15090 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.62 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18640607 | 0.93 | FFAR3 (0.55) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL9754253 | 0.88 | TSHR (0.71) | GPR84PPARGPPARDPPARAHDAC11 | |
| Sebacic Acid SCHEMBL28373760 | 0.83 | GPR84 (0.79) | GPR84PPARGPPARDPPARAHDAC11 | |
| Azelaic Acid SCHEMBL14893174 | 0.83 | GPR84 (0.79) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL740114 | 0.81 | AKR1B1 (0.56) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL24338481 | 0.80 | CES2 (0.48) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL10714923 | 0.80 | LMNA (0.61) | GPR84PPARGPPARDPPARAHDAC11 | |
| Pimelic Acid SCHEMBL1483103 | 0.80 | GPR84 (0.83) | GPR84PPARGPPARDPPARAHDAC11 | |
| Sebacic Acid SCHEMBL2474666 | 0.80 | GPR84 (0.83) | GPR84PPARGPPARDPPARAHDAC11 | |
| Sebacic Acid SCHEMBL19066940 | 0.80 | GPR84 (0.83) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296946-B1 | AMINOTHIOLESTER COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES THEREOF | GALDERMA RES & DEV (FR) | 2004-04-21 | — | — | EP | claimed |
| EP-1296946-A1 | AMINOTHIOLESTER COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES THEREOF | Galderma Research & Development, S.N.C. (FR) | 2003-04-02 | — | — | EP | claimed |
| WO-2001092220-A1 | AMINOTHIOLESTER COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2001-12-06 | — | — | WO | claimed |
| EP-0947503-B1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | GALDERMA RES & DEV (FR) | 2001-11-21 | — | — | EP | claimed |
| US-6117902-A | 6,8-dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical and pharmaceutical compositions intended for the treatment of cancerous tumors | GALDERMAN RESEARCH & DEVELOPMENT, S.N.C. SOPHIA ABTIPOLIS (FR) | 2000-09-12 | — | — | US | claimed |
| EP-0947503-A1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | Galderma Research & Development, S.N.C. (FR) | 1999-10-06 | — | — | EP | claimed |
| EP-1296946-B1 | AMINOTHIOLESTER COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES THEREOF | GALDERMA RES & DEV (FR) | 2004-04-21 | — | — | EP | disclosed |
| EP-1296946-A1 | AMINOTHIOLESTER COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES THEREOF | Galderma Research & Development, S.N.C. (FR) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001092220-A1 | AMINOTHIOLESTER COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES THEREOF | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2001-12-06 | — | — | WO | disclosed |
| EP-0947503-B1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | GALDERMA RES & DEV (FR) | 2001-11-21 | — | — | EP | disclosed |
| US-6117902-A | 6,8-dimercaptooctanoic acid derivatives substituted at the 6-S and/or 8-S position with the (3-methylthiopropanoyl) radical and pharmaceutical compositions intended for the treatment of cancerous tumors | GALDERMAN RESEARCH & DEVELOPMENT, S.N.C. SOPHIA ABTIPOLIS (FR) | 2000-09-12 | — | — | US | disclosed |
| EP-0947503-A1 | 6,8-Dimethylmercaptooctanoic acid derivatives substituted on 6-S and/or 8-S by the 3-methylthiopropanoyl radical and pharmaceutical compositions for the treatment of cancerous tumours | Galderma Research & Development, S.N.C. (FR) | 1999-10-06 | — | — | EP | disclosed |