Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.48 |
| ▸ | RAF1 | P04049 | 9/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572665 | 0.92 | RAF1 (0.49) | BRAFRAF1 | |
| SCHEMBL6570490 | 0.92 | RAF1 (0.47) | BRAFRAF1MAPK14 | |
| SCHEMBL6572676 | 0.88 | RAF1 (0.46) | BRAFRAF1MAPK14 | |
| SCHEMBL6574089 | 0.85 | OPRK1 (0.44) | BRAFRAF1 | |
| SCHEMBL6574087 | 0.83 | RAF1 (0.44) | BRAFRAF1MAPK14 | |
| SCHEMBL6477083 | 0.81 | MAPK14 (0.54) | BRAFMAPK14CYP3A4CYP2C9 | |
| SCHEMBL6571705 | 0.80 | OPRK1 (0.51) | BRAFRAF1MAPK14 | |
| SCHEMBL6477326 | 0.75 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL6484225 | 0.74 | MAPK14 (0.52) | MAPK14 | |
| SCHEMBL7805559 | 0.74 | OPRK1 (0.46) | BRAFRAF1MAPK14PLAUCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | disclosed |