Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570490 | 0.93 | RAF1 (0.47) | OPRK1BRAFRAF1 | |
| SCHEMBL6572676 | 0.89 | RAF1 (0.46) | OPRK1BRAFRAF1 | |
| SCHEMBL6572660 | 0.85 | BRAF (0.48) | BRAFRAF1 | |
| SCHEMBL6572665 | 0.84 | RAF1 (0.49) | CSF1RPDGFRBKITDDR1BRAF | |
| SCHEMBL6574087 | 0.83 | RAF1 (0.44) | OPRK1BRAFRAF1 | |
| SCHEMBL6571705 | 0.81 | OPRK1 (0.51) | OPRK1BRAFRAF1 | |
| SCHEMBL6477163 | 0.80 | OPRK1 (0.58) | OPRK1GPR119CSF1RPDGFRBKIT | |
| SCHEMBL6477601 | 0.80 | OPRK1 (0.57) | OPRK1GPR119CSF1RPDGFRBKIT | |
| SCHEMBL6477326 | 0.75 | MAPK14 (0.54) | OPRK1THRB | |
| SCHEMBL21391326 | 0.74 | KIT (0.57) | GPR119CSF1RPDGFRBKITDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | disclosed |