Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.49 |
| ▸ | BRAF | P15056 | 17/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572660 | 0.92 | BRAF (0.48) | RAF1BRAF | |
| SCHEMBL6570490 | 0.91 | RAF1 (0.47) | RAF1BRAF | |
| SCHEMBL6572676 | 0.87 | RAF1 (0.46) | RAF1BRAF | |
| SCHEMBL6574089 | 0.84 | OPRK1 (0.44) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL6574087 | 0.82 | RAF1 (0.44) | RAF1BRAF | |
| SCHEMBL6486522 | 0.81 | CSF1R (0.58) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL6571705 | 0.79 | OPRK1 (0.51) | RAF1BRAF | |
| SCHEMBL20707292 | 0.75 | KIT (0.75) | RAF1BRAFCSF1RPDGFRBKIT | |
| SCHEMBL6477326 | 0.74 | MAPK14 (0.54) | — | |
| SCHEMBL6477083 | 0.73 | MAPK14 (0.54) | BRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | disclosed |