Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29363181 | 0.90 | RAB9A (0.61) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL59309 | 0.90 | RAB9A (0.61) | NPC1RAB9ALMNAPOLBKDM4E | |
| Methane SCHEMBL10729260 | 0.88 | RAB9A (0.59) | NPC1RAB9ALMNAPOLBKDM4E | |
| Drometrizole SCHEMBL6667186 | 0.88 | NPC1 (0.80) | NPC1RAB9ALMNAPOLBKDM4E | |
| Acetic Acid SCHEMBL2228922 | 0.84 | NPC1 (0.56) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL10892228 | 0.80 | NPC1 (0.49) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL12415218 | 0.80 | NPC1 (0.51) | NPC1RAB9ALMNAPOLBKDM4E | |
| Drometrizole SCHEMBL7796640 | 0.80 | NPC1 (0.90) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL7783965 | 0.79 | NPC1 (0.44) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL27716246 | 0.78 | RAB9A (0.57) | NPC1RAB9ALMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5980851-A | Transparent electrically conductive plate | NIPPON OIL, CO., LTD. (JP) | 1999-11-09 | — | — | US | claimed |
| US-5770314-A | Transparent electrically conductive plate | NIPPON OIL CO., LTD. (JP) | 1998-06-23 | — | — | US | claimed |
| EP-0752612-B1 | Electrochromic device | NIPPON MITSUBISHI OIL CORP (JP) | 2004-04-21 | — | — | EP | disclosed |
| EP-0736794-B1 | Transparent electrically conductive plate | NIPPON MITSUBISHI OIL CORP (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-5980851-A | Transparent electrically conductive plate | NIPPON OIL, CO., LTD. (JP) | 1999-11-09 | — | — | US | disclosed |
| EP-0732361-B1 | Ultraviolet absorber and coating material | NIPPON OIL CO LTD (JP) | 1999-10-06 | — | — | EP | disclosed |
| US-5859722-A | Electrochromic device | NIPPOM OIL CO., LTD (JP) | 1999-01-12 | — | — | US | disclosed |
| US-5770314-A | Transparent electrically conductive plate | NIPPON OIL CO., LTD. (JP) | 1998-06-23 | — | — | US | disclosed |
| US-5627227-A | Ultraviolet absorber and coating material | NIPPON OIL CO., LTD. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0752612-A1 | Electrochromic device | NIPPON OIL CO., LTD. (JP) | 1997-01-08 | — | — | EP | disclosed |
| EP-0736794-A2 | Transparent electrically conductive plate | NIPPON OIL CO., LTD. (JP) | 1996-10-09 | — | — | EP | disclosed |
| EP-0732361-A1 | Ultraviolet absorber and coating material | NIPPON OIL CO., LTD. (JP) | 1996-09-18 | — | — | EP | disclosed |