Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21563118 | 0.73 | CHRM1 (0.36) | CHRM1SLC6A2SLC6A4 | |
| SCHEMBL6617342 | 0.72 | MAPK1 (0.59) | MAPK1MEN1KMT2A | |
| SCHEMBL4351591 | 0.71 | MAPK1 (0.41) | MAPK1MEN1KMT2A | |
| SCHEMBL5071115 | 0.71 | MAPK1 (0.46) | MAPK1MEN1KMT2A | |
| SCHEMBL5965398 | 0.71 | AR (0.38) | MAPK1MEN1KMT2A | |
| SCHEMBL22525171 | 0.70 | LMNA (0.56) | CHRM1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL17752569 | 0.70 | LMNA (0.34) | CHRM1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL22839050 | 0.70 | LMNA (0.34) | CHRM1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6153609 | 0.68 | DRD2 (0.50) | SLC6A2 | |
| SCHEMBL28641227 | 0.68 | MAPK1 (0.43) | MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051417-B1 | PROCESS FOR THE PREPARATION OF 8-AZABICYCLO(3.2.1)OCTANE DERIVATIVES | SYNGENTA LTD (GB) | 2004-11-03 | — | — | EP | disclosed |
| US-6323343-B1 | REACING 8-(HALOUOROETHYL)-8-AZABICYCLO(3.2.1)OCTAN-3-ONE WITH ALKALI METAL CYANIDE IN PRESENCE OF ACID AND BASE, 3-CYANO-3-HYDROXY-8-(2,2,2-TRIFLUOROETHYL)-8-AZABICYCLO(3.2.1) OCTANE | SYNGENTA LIMITED (GB) | 2001-11-27 | — | — | US | disclosed |
| EP-1051417-A1 | PROCESS FOR THE PREPARATION OF 8-AZABICYCLO(3.2.1)OCTANE DERIVATIVES | ZENECA LIMITED (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999029690-A1 | PROCESS FOR THE PREPARATION OF 8-AZABICYCLO(3.2.1)OCTANE DERIVATIVES | ZENECA LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |