SCHEMBL6573384

SCHEMBL6573384

Nc1ccc(NCCO)c(-c2cccc(Cl)c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 5/20 0.51
STK4 Q13043 2/20 0.42
STK3 Q13188 2/20 0.42
LRRK2 Q5S007 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
PKM P14618 1/20 0.41
KMT2A Q03164 1/20 0.41
ALDH1A1 P00352 2/20 0.40
TDO2 P48775 1/20 0.38
ADORA2A P29274 1/20 0.38
DHFR P00374 1/20 0.38
MAOB P27338 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
NUDT1 P36639 1/20 0.37
SRC P12931 1/20 0.37
TAAR1 Q96RJ0 1/20 0.36
MAPT P10636 1/20 0.36
RECQL P46063 1/20 0.36
BLM P54132 1/20 0.36
CDK5 Q00535 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574148 0.90 KDM4E (0.41) ADORA1SMN1; SMN2ALDH1A1MAPTRECQL
SCHEMBL6571420 0.85 MKNK1 (0.37) ADORA1SMN1; SMN2PKMKMT2AALDH1A1
SCHEMBL6570922 0.85 PTGDR2 (0.44) ADORA1ALDH1A1RECQL
SCHEMBL6570749 0.84 PIK3CG (0.41) ADORA1STK3LRRK2ALDH1A1SRC
Hydrochloric Acid SCHEMBL6573152 0.84 PTGDR2 (0.43) ADORA1SMN1; SMN2ALDH1A1RECQL
SCHEMBL6570923 0.83 MAPT (0.37) ADORA1SMN1; SMN2KMT2AALDH1A1L3MBTL1
SCHEMBL6570636 0.83 TAAR1 (0.45) ADORA1SRCTAAR1MAPT
SCHEMBL6571957 0.82 PRSS1 (0.38) KMT2AALDH1A1RECQL
SCHEMBL6572450 0.82 ADORA1 (0.37) ADORA1STK4STK3LRRK2ALDH1A1
SCHEMBL6571430 0.81 PRSS1 (0.37) KMT2AALDH1A1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed