SCHEMBL6570922

SCHEMBL6570922

Nc1ccc(NCCO)c(-c2ccccc2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.44
MAOA P21397 1/20 0.41
CYP2C19 P33261 1/20 0.40
ADORA1 P30542 1/20 0.39
TOP2B Q02880 1/20 0.39
MAP4K4 O95819 1/20 0.38
TYK2 P29597 1/20 0.38
MINK1 Q8N4C8 1/20 0.38
SRPK1 Q96SB4 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38
ALDH1A1 P00352 3/20 0.38
GAA P10253 3/20 0.38
KDM4E B2RXH2 3/20 0.38
GLA P06280 3/20 0.38
RECQL P46063 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
HTT P42858 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6573152 0.98 PTGDR2 (0.43) PTGDR2MAOACYP2C19ADORA1TOP2B
SCHEMBL6574148 0.92 KDM4E (0.41) PTGDR2MAOAADORA1TOP2BMAP4K4
SCHEMBL6571957 0.90 PRSS1 (0.38) PTGDR2TOP2BALDH1A1KDM4ERECQL
SCHEMBL6571430 0.88 PRSS1 (0.37) PTGDR2CYP2C19TOP2BTYK2ALDH1A1
SCHEMBL6570749 0.86 PIK3CG (0.41) CYP2C19ADORA1MAP4K4MINK1SRPK1
SCHEMBL6571342 0.85 USP7 (0.40) ALDH1A1GAAKDM4EGLAHPGD
SCHEMBL7085552 0.85 MKNK2 (0.50) MAP4K4MINK1CLK4ALDH1A1HPGD
SCHEMBL6573384 0.85 ADORA1 (0.51) ADORA1ALDH1A1RECQL
SCHEMBL6570636 0.85 TAAR1 (0.45) ADORA1POLB
SCHEMBL6570923 0.85 MAPT (0.37) PTGDR2ADORA1MAP4K4ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed