Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17766325 | 0.83 | RAB9A (0.52) | SMN1; SMN2NPC1RAB9ATSHRHPGD | |
| SCHEMBL5111754 | 0.81 | ADORA2A (0.52) | ADORA2AALDH1A1NCF1TSHRKMT2A | |
| SCHEMBL17864829 | 0.80 | TSHR (0.50) | SMN1; SMN2NPC1RAB9ATSHRHPGD | |
| SCHEMBL27645336 | 0.79 | RAB9A (0.48) | SMN1; SMN2NPC1RAB9ATSHRHPGD | |
| SCHEMBL14499027 | 0.78 | RAB9A (0.47) | SMN1; SMN2NPC1RAB9ATSHRHPGD | |
| SCHEMBL2035838 | 0.77 | PPID (0.58) | ADORA2ASMN1; SMN2RAB9AMAPTALDH1A1 | |
| SCHEMBL17863589 | 0.77 | EPHX2 (0.49) | SMN1; SMN2NPC1RAB9ATSHRHPGD | |
| SCHEMBL14270321 | 0.76 | MMP13 (0.49) | SMN1; SMN2NPC1RAB9AMMP13ALDH1A1 | |
| SCHEMBL26224788 | 0.76 | RAB9A (0.45) | SMN1; SMN2NPC1RAB9ATSHRHPGD | |
| SCHEMBL18124428 | 0.75 | TSHR (0.51) | SMN1; SMN2ALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435942-A1 | 5'-CARBAMOYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032980-A1 | 5'-CARBAMOYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |