Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572084 | 0.86 | CYP2C19 (0.49) | MAPTALDH1A1LMNAGAACYP2C19 | |
| SCHEMBL6569993 | 0.78 | LMNA (0.68) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL15574248 | 0.78 | THRB (0.40) | MAPTALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL15573363 | 0.78 | KMT2A (0.39) | MAPTALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL15574219 | 0.78 | LMNA (0.39) | ALDH1A1LMNAL3MBTL1GAACYP2C19 | |
| SCHEMBL5827633 | 0.78 | MAPT (0.67) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL6572262 | 0.77 | SMN1; SMN2 (0.69) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL6573527 | 0.76 | SMN1; SMN2 (0.65) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL28153041 | 0.74 | KDM4E (0.61) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL15573622 | 0.73 | THRB (0.38) | MAPTALDH1A1LMNACYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109550-B1 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2004-11-24 | — | — | EP | disclosed |
| US-6517836-B1 | Aziridin-1-yl nitrobenzamides as prodrugs in conjunction with nitroreductase enzymes | AUCKLAND UNISERVICES LIMITED (NZ) | 2003-02-11 | — | — | US | disclosed |
| EP-1109550-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000013683-A2 | NOVEL NITROPHENYLAZIRIDINE COMPOUNDS AND THEIR USE AS PRODRUGS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-16 | — | — | WO | disclosed |