Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD known ✓ | O00329 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 14/20 | 0.93 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332442 | 0.96 | ALOX5 (1.00) | ALOX5PIK3CD | |
| SCHEMBL29405839 | 0.96 | ALOX5 (1.00) | ALOX5PIK3CD | |
| Hydrochloric Acid SCHEMBL8173877 | 0.95 | ALOX5 (0.98) | ALOX5PIK3CD | |
| SCHEMBL7802832 | 0.88 | ALOX5 (0.84) | ALOX5 | |
| SCHEMBL8173639 | 0.88 | ALOX5 (0.80) | ALOX5 | |
| SCHEMBL15803500 | 0.87 | ALOX5 (0.82) | ALOX5 | |
| SCHEMBL14678487 | 0.85 | ALOX5 (0.79) | ALOX5PIK3CD | |
| SCHEMBL7807543 | 0.84 | ALOX5 (0.78) | ALOX5 | |
| SCHEMBL8781493 | 0.84 | ALOX5 (0.78) | ALOX5 | |
| SCHEMBL7807539 | 0.84 | ALOX5 (0.78) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1029865-B1 | Process for preparing 5-lipoxygenase inhibitors | PFIZER PROD INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6346624-B1 | ENZYME INHIBITORS FORMED BY DEHYDROHALOGENATION | PFIZER INC | 2002-02-12 | — | — | US | disclosed |
| US-6344563-B1 | SULFIDING, DEHYDROHALOGENATION, FORMATION OF BOND BETWEEN CARBON AND NITROGEN | NORRIS TIMOTHY (US) | 2002-02-05 | — | — | US | disclosed |
| US-6239285-B1 | REACTING A TETRAHYDRO-4-(3-(4-FLUOROPHENYL)THIO)PHENYL-2H-PYRAN-4-CARBOXA MIDE WITH HETEROCYCLE RING | PFIZER INC | 2001-05-29 | — | — | US | disclosed |
| CN-1291609-A | Method of preparing 5-lipoxidase inhibitor possessing different heterocyclic ring system | PFIZER PROD INC (US) | 2001-04-18 | — | — | CN | disclosed |
| EP-1081146-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1081143-A1 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1081144-A2 | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems | Pfizer Products Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| CN-1286250-A | Method for preparing 5-lipooxygenase inhibitor having changeable heterocycle system | PFIZER PROD INC (US) | 2001-03-07 | — | — | CN | disclosed |
| US-6194585-B1 | REACTING 4-(3-(4-(2-(ALKYL OR ARYL-IMIDAZOL-1-YL)-PHENYL SULFANYL)-PHENYL)-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID AMIDE WITH METHANESULFONIC ACID TO FORM CORRESPONDING METHANESULFONIC ACID | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1029865-A2 | Process and intermediates for preparing 5-lipoxygenase inhibitors | Pfizer Products Inc. (US) | 2000-08-23 | — | — | EP | disclosed |