Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6572880 | 0.99 | POLB (0.36) | POLBCYP2C9CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL7635538 | 0.90 | POLB (0.36) | POLBCYP2C9KMT2AMEN1RECQL | |
| Hydrochloric Acid SCHEMBL6944704 | 0.89 | LMNA (0.37) | POLBCYP2C9CA1CA2CA9 | |
| SCHEMBL6946188 | 0.88 | SMN1; SMN2 (0.38) | POLBCYP2C9CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL6573701 | 0.87 | LMNA (0.38) | POLBKMT2AMEN1RECQLALDH1A1 | |
| Hydrochloric Acid SCHEMBL6572979 | 0.86 | CYP1A2 (0.39) | POLBCYP2C9KMT2AMEN1RECQL | |
| SCHEMBL6573683 | 0.85 | LMNA (0.36) | POLBKMT2AMEN1RECQLALDH1A1 | |
| SCHEMBL6571520 | 0.85 | CYP1A2 (0.40) | POLBCYP2C9KMT2AMEN1RECQL | |
| Hydrochloric Acid SCHEMBL6572670 | 0.84 | MEN1 (0.37) | KMT2AMEN1RECQLALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL6572788 | 0.83 | MEN1 (0.38) | KMT2AMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066263-B1 | NOVEL CATIONIC 2-ACYLAMINOPHENOLS, THEIR USE AS COUPLER FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM, AND DYEING METHODS | OREAL (FR) | 2004-05-26 | — | — | EP | claimed |
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | claimed |
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | disclosed |