Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 4/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6573909 | 0.90 | POLB (0.38) | POLBCYP2C9MEN1KMT2ALMNA | |
| SCHEMBL6572880 | 0.89 | POLB (0.36) | POLBCYP2C9MEN1KMT2ARECQL | |
| Hydrochloric Acid SCHEMBL6940001 | 0.89 | LMNA (0.36) | POLBCYP2C9MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL7632203 | 0.89 | CYP1A2 (0.39) | POLBCYP2C9MEN1KMT2ARECQL | |
| Hydrochloric Acid SCHEMBL7628910 | 0.88 | LMNA (0.37) | POLBMEN1KMT2ALMNARECQL | |
| SCHEMBL6943539 | 0.88 | LMNA (0.37) | POLBCYP2C9MEN1KMT2ALMNA | |
| SCHEMBL7805138 | 0.87 | CYP1A2 (0.40) | POLBCYP2C9MEN1KMT2ARECQL | |
| Hydrochloric Acid SCHEMBL6573008 | 0.84 | MAPT (0.43) | POLBMEN1KMT2ALMNARECQL | |
| SCHEMBL6572655 | 0.83 | MAPT (0.44) | POLBMEN1KMT2ALMNARECQL | |
| Hydrochloric Acid SCHEMBL6938954 | 0.83 | ALDH1A1 (0.45) | POLBCYP2C9MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | claimed |
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | disclosed |