SCHEMBL6573975

SCHEMBL6573975

COc1cc(OC)nc(NC(=O)NS(=O)(=O)Nc2ccc(F)cc2C(=O)C2CC2)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.54
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CDK1 P06493 1/20 0.39
PIK3CA P42336 2/20 0.38
CYP1A2 P05177 1/20 0.38
ALDH1A1 P00352 1/20 0.37
MRGPRX1 Q96LB2 2/20 0.37
TSPO P30536 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
TP53 P04637 1/20 0.36
GLA P06280 1/20 0.36
MAPT P10636 1/20 0.36
ALOX15 P16050 1/20 0.36
PIK3CD O00329 1/20 0.35
PIK3CB P42338 1/20 0.35
MTOR P42345 1/20 0.35
PIK3CG P48736 1/20 0.35
HCRTR1 O43613 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8539345 0.89 GAA (0.45) GAAHTTCDK1CYP1A2ALDH1A1
SCHEMBL8539307 0.89 GAA (0.44) GAAHTTSMN1; SMN2CDK1CYP1A2
SCHEMBL29510603 0.88 GAA (0.47) GAASMN1; SMN2CDK1CYP1A2ALDH1A1
SCHEMBL53468 0.88 GAA (0.47) GAASMN1; SMN2CDK1CYP1A2ALDH1A1
SCHEMBL6812884 0.87 GAA (0.47) GAASMN1; SMN2CDK1CYP1A2ALDH1A1
SCHEMBL8538021 0.87 GAA (0.43) GAACDK1CYP1A2ALDH1A1TP53
SCHEMBL6573963 0.85 NPC1 (0.36) GAAMRGPRX1TSPONPC1RAB9A
SCHEMBL7806393 0.84 GAA (0.56) GAAHTTSMN1; SMN2CDK1CYP1A2
SCHEMBL9316190 0.79 GAA (0.48) GAACDK1CYP1A2ALDH1A1NPC1
Ethoxysulfuron SCHEMBL6447158 0.79 MRGPRX1 (0.41) GAAMRGPRX1TSPOTP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0679646-B1 Sulfonyl ureas as herbicidal compounds AMERICAN CYANAMID CO (US) 1998-07-29 EP claimed
US-5492884-A PREEMERGENCE, POSTEMERGENCE AMERICAN CYANAMID COMPANY (US) 1996-02-20 US claimed
EP-0679646-A1 Sulfonyl ureas as herbicidal compounds AMERICAN CYANAMID COMPANY (US) 1995-11-02 EP claimed
JP-7304754-A None JP disclosed
JP-7304754-A None JP disclosed
EP-0747365-B1 Process and intermediates for the manufacture of herbicidal 1- [2-(cyclopropylcarbonyl)phenyl] sulfamoyl -3-(4,6-dialkoxy-2-pyrimidinyl)urea compounds BASF AG (DE) 2004-08-11 EP disclosed
CN-1067382-C 1-{[2-(cyclopropylcarbonyl)-4-fluorophenyl] sulfamoyl}-3-(4,6-Dimethoxy-2-pyrimidinyl)urea and itsd herbicidal AMERICAN CYANAMID CO (US) 2001-06-20 CN disclosed
CN-1067382-C 1-{[2-(cyclopropylcarbonyl)-4-fluorophenyl] sulfamoyl}-3-(4,6-Dimethoxy-2-pyrimidinyl)urea and itsd herbicidal AMERICAN CYANAMID CO (US) 2001-06-20 CN disclosed
US-6143694-A AIDING RIPENING OF TOBACCO PLANT BY PREHARVEST APPLICATION OF NON-PHYTOTOXIC AMOUNT OF 2-(4,5-DIHYDRO-4-METHYL-4-(1-METHYLETHYL)-5-OXO-1H-IMIDAZOL-2 -YL)ARYLCARBOXYLATE TAYLOR JOHN B (US) 2000-11-07 US disclosed
US-5847140-A Intermediates for the manufacture of herbicidal 1-{ 2-(cyclopropylcarbonyl) Phenyl! Sulfamoyl}-3-(4,6-dialkoxy-2-pyrimidinyl) urea compounds AMERICAN CYANAMID COMPANY (US) 1998-12-08 US disclosed
EP-0679646-B1 Sulfonyl ureas as herbicidal compounds AMERICAN CYANAMID CO (US) 1998-07-29 EP disclosed
US-5492884-A PREEMERGENCE, POSTEMERGENCE AMERICAN CYANAMID COMPANY (US) 1996-02-20 US disclosed
US-5492884-A PREEMERGENCE, POSTEMERGENCE AMERICAN CYANAMID COMPANY (US) 1996-02-20 US disclosed
CN-1112923-A 1-{[2-(cyclopropylcarbonyl)-4-fluorophenyl] sulfamoyl}-3-(4,6-Dimethoxy-2-pyrimidinyl)urea and itsd herbicidal AMERICAN CYANAMID CO (US) 1995-12-06 CN disclosed
CN-1112923-A 1-{[2-(cyclopropylcarbonyl)-4-fluorophenyl] sulfamoyl}-3-(4,6-Dimethoxy-2-pyrimidinyl)urea and itsd herbicidal AMERICAN CYANAMID CO (US) 1995-12-06 CN disclosed
CN-1112923-A 1-{[2-(cyclopropylcarbonyl)-4-fluorophenyl] sulfamoyl}-3-(4,6-Dimethoxy-2-pyrimidinyl)urea and itsd herbicidal AMERICAN CYANAMID CO (US) 1995-12-06 CN disclosed
JP-H07304754-A 1-((2-(CYCLOPROPYLCARBONYL)-4-FLUOROPHENYL)SULFAMOYL)-3-(4,6-DIMETHOXY2-PYRIMIDINYL) UREA AND ITS HERBICIDAL USE AMERICAN CYANAMID CO 1995-11-21 JP disclosed
JP-H07304754-A 1-((2-(CYCLOPROPYLCARBONYL)-4-FLUOROPHENYL)SULFAMOYL)-3-(4,6-DIMETHOXY2-PYRIMIDINYL) UREA AND ITS HERBICIDAL USE AMERICAN CYANAMID CO 1995-11-21 JP disclosed
EP-0679646-A1 Sulfonyl ureas as herbicidal compounds AMERICAN CYANAMID COMPANY (US) 1995-11-02 EP disclosed
EP-0679646-A1 Sulfonyl ureas as herbicidal compounds AMERICAN CYANAMID COMPANY (US) 1995-11-02 EP disclosed