Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10633126 | 1.00 | TSHR (0.45) | TSHRKMT2AHPGDMEN1GPR139 | |
| SCHEMBL10908312 | 0.86 | TSHR (0.43) | TSHRKMT2AHPGDMEN1GPR139 | |
| SCHEMBL16250754 | 0.85 | GPR139 (0.45) | TSHRKMT2AHPGDMEN1GPR139 | |
| SCHEMBL16236134 | 0.85 | GPR139 (0.45) | TSHRKMT2AHPGDMEN1GPR139 | |
| SCHEMBL25627291 | 0.83 | GPR139 (0.44) | TSHRKMT2AHPGDMEN1GPR139 | |
| SCHEMBL28151451 | 0.82 | NR4A2 (0.48) | TSHRKMT2AGPR139NR4A2ALDH1A1 | |
| SCHEMBL19264805 | 0.81 | GPR139 (0.43) | TSHRKMT2AHPGDMEN1GPR139 | |
| SCHEMBL18113153 | 0.80 | KMT2A (0.49) | TSHRKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL28180788 | 0.80 | RAB9A (0.43) | TSHRKMT2AHPGDGPR139NR4A2 | |
| SCHEMBL16044915 | 0.78 | MAPT (0.45) | TSHRKMT2AHPGDMEN1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0870762-B1 | NOVEL AMINO ACID DERIVATIVES HAVING N,N-DIALKYLAMINOPHENYL GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2004-04-28 | — | — | EP | disclosed |
| US-5872281-A | COMPOUNDS FOR TREATMENT OF RHEUMATIC DISEASES, PSORIASIS, INTESTINAL INFLAMATION | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1999-02-16 | — | — | US | disclosed |
| EP-0870762-A1 | NOVEL AMINO ACID DERIVATIVES HAVING N,N-DIALKYLAMINOPHENYL GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1998-10-14 | — | — | EP | disclosed |