Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 2/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14453825 | 0.75 | TAAR1 (0.50) | GABBR2GABBR1TAAR1HTR2ACYP1A2 | |
| SCHEMBL6931929 | 0.73 | CASR (0.49) | CASRCYP1A2NPSR1TSHRCYP2C19 | |
| SCHEMBL1906076 | 0.73 | MEN1 (0.44) | TAAR1HTR2ACASRCYP2D6SMN1; SMN2 | |
| SCHEMBL20241505 | 0.73 | CASR (0.37) | TAAR1HTR2ACASRCYP1A2CYP2D6 | |
| SCHEMBL7158465 | 0.73 | CASR (0.40) | TAAR1HTR2ACASRCYP1A2CYP2D6 | |
| SCHEMBL11434362 | 0.73 | CASR (0.40) | HTR2ACASRCYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL17075263 | 0.72 | CASR (0.46) | CASRCYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL16617907 | 0.72 | CASR (0.48) | CASRCYP2D6PKMSMN1; SMN2NPSR1 | |
| SCHEMBL18642721 | 0.72 | GABBR2 (0.47) | GABBR2GABBR1TAAR1HTR2ACYP1A2 | |
| SCHEMBL793949 | 0.72 | SLC6A2 (0.44) | CASRCYP1A2CYP2D6SMN1; SMN2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154983-B1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-04-28 | — | — | EP | disclosed |
| EP-1154983-B1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6441237-B1 | DRUGS; ANTIARRHTHYMIA AGENTS, ANTIISCHEMIC AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-08-27 | — | — | US | disclosed |
| US-6441237-B1 | DRUGS; ANTIARRHTHYMIA AGENTS, ANTIISCHEMIC AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-08-27 | — | — | US | disclosed |
| US-6441237-B1 | DRUGS; ANTIARRHTHYMIA AGENTS, ANTIISCHEMIC AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-08-27 | — | — | US | disclosed |
| EP-1154983-A1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-21 | — | — | EP | disclosed |
| EP-1154983-A1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000048987-A1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-08-24 | — | — | WO | disclosed |
| WO-2000048987-A1 | NOVEL SUBSTITUTED 3-PHENOXY AND 3-PHENYLALKYLOXY-2-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-08-24 | — | — | WO | disclosed |