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SCHEMBL6574353

SCHEMBL6574353

CC(C)CC(CNC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NC1CCCCC1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 14/20 0.76
▸ MMP8 P22894 12/20 0.76
▸ MMP9 P14780 11/20 0.76
▸ MMP1 P03956 4/20 0.60
▸ ECE1 P42892 1/20 0.59
▸ MMP3 P08254 3/20 0.57
▸ ADAM10 O14672 1/20 0.56
▸ ADAM12 O43184 1/20 0.56
▸ ADAMTS4 O75173 1/20 0.56
▸ MMP7 P09237 1/20 0.56
▸ MMP12 P39900 1/20 0.56
▸ MMP13 P45452 1/20 0.56
▸ MMP14 P50281 1/20 0.56
▸ MMP15 P51511 1/20 0.56
▸ MMP16 P51512 1/20 0.56
▸ ADAM17 P78536 1/20 0.56
▸ ADAM9 Q13443 1/20 0.56
▸ MMP26 Q9NRE1 1/20 0.56
▸ MMP17 Q9ULZ9 1/20 0.56
▸ ADAMTS5 Q9UNA0 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7765890 0.85 MMP2 (0.80) MMP2MMP8MMP9MMP1ECE1
SCHEMBL6439250 0.85 MMP2 (0.80) MMP2MMP8MMP9MMP1ECE1
SCHEMBL6577614 0.85 MMP2 (0.80) MMP2MMP8MMP9MMP1ECE1
SCHEMBL6431194 0.85 ECE1 (0.79) MMP2MMP8MMP9MMP1ECE1
SCHEMBL6438804 0.83 MMP1 (0.67) MMP2MMP8MMP9MMP1ECE1
SCHEMBL6435290 0.81 ECE1 (0.64) MMP2MMP8MMP9MMP1ECE1
SCHEMBL6575670 0.80 MMP1 (0.84) MMP2MMP8MMP9MMP1ECE1
SCHEMBL22116486 0.79 SIRT5 (0.56) MMP2MMP8MMP9HDAC3HDAC4
SCHEMBL22116478 0.79 SIRT5 (0.56) MMP2MMP8MMP9HDAC3HDAC4
SCHEMBL7193888 0.78 TACR1 (0.69) MMP2MMP8MMP9MMP1ECE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0558648-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 2004-04-28 — — EP disclosed
EP-0663823-B1 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 2000-11-22 — — EP disclosed
EP-0558681-B1 TREATMENT FOR TISSUE ULCERATION UNIV FLORIDA (US) 1998-04-08 — — EP disclosed
EP-0663823-A4 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS. GLYCOMED INC (US) 1997-06-04 — — EP disclosed
EP-0663823-A1 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INCORPORATED (US) 1995-07-26 — — EP disclosed
WO-1994022309-A1 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INCORPORATED (US) 1994-10-13 — — WO disclosed
US-5270326-A Administering inhibitor of mammalian matrix metalloprotease UNIVERSITY OF FLORIDA (US) 1993-12-14 — — US disclosed
US-5268384-A Containing amide groups GLYCOMED, INC., A CA CORP 1993-12-07 — — US disclosed
EP-0558648-A4 IMPROVED MATRIX METALLOPROTEASE INHIBITORS — 1993-11-24 — — EP disclosed
EP-0558648-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY, Richard, E. (US) 1993-09-08 — — EP disclosed
US-5239078-A Collagenase enzyme inhibitors GLYCOMED INCORPORATED (US) 1993-08-24 — — US disclosed
WO-1993013741-A2 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1993-07-22 — — WO disclosed
US-5189178-A Preventing protein destruction GALARDY RICHARD E (US) 1993-02-23 — — US disclosed
US-5183900-A Matrix metalloprotease inhibitors GALARDY RICHARD E (US) 1993-02-02 — — US disclosed
WO-1992009556-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 1992-06-11 — — WO disclosed
US-5114953-A Peptides UNIVERSITY OF FLORIDA (US) 1992-05-19 — — US disclosed