Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573847 | 0.99 | MEN1 (0.42) | KMT2AMEN1RECQLLMNACA12 | |
| Hydrochloric Acid SCHEMBL6942128 | 0.86 | LMNA (0.41) | KMT2AMEN1RECQLLMNACA12 | |
| SCHEMBL6945490 | 0.84 | LMNA (0.41) | KMT2AMEN1RECQLLMNACA12 | |
| Hydrochloric Acid SCHEMBL7636177 | 0.84 | KMT2A (0.39) | KMT2AMEN1RECQLLMNACA12 | |
| Hydrochloric Acid SCHEMBL6571648 | 0.83 | MEN1 (0.36) | KMT2AMEN1RECQLLMNAALDH1A1 | |
| SCHEMBL6575589 | 0.82 | MEN1 (0.37) | KMT2AMEN1RECQLLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL6572793 | 0.81 | KMT2A (0.47) | KMT2AMEN1RECQLLMNAALDH1A1 | |
| SCHEMBL6574287 | 0.80 | KMT2A (0.48) | KMT2AMEN1RECQLLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL6944402 | 0.79 | KMT2A (0.54) | KMT2AMEN1LMNAALDH1A1MAPK1 | |
| Bromide SCHEMBL22408334 | 0.79 | CA12 (0.47) | KMT2AMEN1RECQLLMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066263-B1 | NOVEL CATIONIC 2-ACYLAMINOPHENOLS, THEIR USE AS COUPLER FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM, AND DYEING METHODS | OREAL (FR) | 2004-05-26 | — | — | EP | claimed |
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | claimed |
| US-6455737-B1 | CATIONIC DYES AND OXIDATION BASES HAVING INTENSE SHADES OR COLORS AND COLORFASTNESS USED ON HUMAN KERATIN FIBERS SUCH AS HAIR; MULTICOMPARTMENT KITS | L'OREAL S.A. (FR) | 2002-09-24 | — | — | US | disclosed |