Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577643 | 0.83 | CHRM2 (0.60) | CHRM2CHRM1CHRM3CHRM5CHRM4 | |
| SCHEMBL9493619 | 0.80 | LMNA (0.60) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| SCHEMBL23494957 | 0.77 | CHRM1 (0.81) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| SCHEMBL13176563 | 0.77 | CHRM1 (0.81) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| SCHEMBL23494955 | 0.77 | CHRM1 (0.81) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| SCHEMBL17430025 | 0.77 | CHRM1 (0.81) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| SCHEMBL250617 | 0.76 | LMNA (0.77) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| SCHEMBL8872524 | 0.76 | LMNA (0.77) | LMNACYP2D6CYP2C9HSD17B10CHRM2 | |
| SCHEMBL6574291 | 0.75 | CHRM3 (0.54) | CYP2D6CHRM2CHRM1CHRM3CHRM5 | |
| SCHEMBL23494998 | 0.75 | CYP2D6 (0.76) | LMNACYP2D6CYP2C9HSD17B10CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383730-A2 | ANTICHOLINERGIC COMPOUNDS AND METHODS OF USE | Aryx Therapeutics (US) | 2004-01-28 | — | — | EP | claimed |
| WO-2002096855-A2 | ANTICHOLINERGIC COMPOUNDS AND METHODS OF USE | ARYX THERAPEUTICS (US) | 2002-12-05 | — | — | WO | claimed |
| US-20020169208-A1 | Novel anticholinergic compounds and methods of use | ARYX THERAPEUTICS | 2002-11-14 | — | — | US | claimed |
| EP-1383730-A2 | ANTICHOLINERGIC COMPOUNDS AND METHODS OF USE | Aryx Therapeutics (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2002096855-A2 | ANTICHOLINERGIC COMPOUNDS AND METHODS OF USE | ARYX THERAPEUTICS (US) | 2002-12-05 | — | — | WO | disclosed |
| US-20020169208-A1 | Novel anticholinergic compounds and methods of use | ARYX THERAPEUTICS | 2002-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169208-A1 | Novel anticholinergic compounds and methods of use | CHRM3, CHRM5, CHRM2 | LMNA 3712/4885CYP2D6 1150/4885CYP2C9 3520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.