Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.39 |
| ▸ | RARG | P13631 | 6/20 | 0.39 |
| ▸ | RARA | P10276 | 4/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616759 | 0.89 | RARB (0.42) | RARBRARGRARAGRM5CYP26A1 | |
| SCHEMBL6574397 | 0.83 | RARA (0.37) | RARBRARGRARA | |
| SCHEMBL6578025 | 0.80 | RARB (0.65) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8616526 | 0.77 | RARB (0.42) | RARBRARGRARAGABRA1GABRG2 | |
| SCHEMBL6576434 | 0.76 | RARB (0.48) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6578008 | 0.76 | RARB (0.51) | RARBRARGRARAGRM5CYP26A1 | |
| SCHEMBL6578064 | 0.76 | HTR2B (0.34) | CYP3A4PIK3CAGABRA1 | |
| SCHEMBL6578640 | 0.76 | RARB (0.49) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6578028 | 0.73 | RARB (0.41) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6575696 | 0.72 | RARB (0.46) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937045-B1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5739338-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS, VISION DEFECTS, VIRICIDES, IMMUNOSUPPRESSANTS | ALLERGAN (US) | 1998-04-14 | — | — | US | disclosed |